scutellarin

Scutellarin is a flavonoid glucuronide, specifically the 7-O-glucuronide of scutellarein, found primarily in the traditional Chinese medicinal plants *Erigeron breviscapus* and *Scutellaria barbata*. It is the principal active component of breviscapine tablets. Scutellarin exhibits a broad spectrum of pharmacological activities, including antioxidant, anti-inflammatory, anti-apoptotic, vasodilatory, antiplatelet, anticoagulant, and myocardial protective effects. Mechanistically, it modulates multiple biological pathways such as oxidative stress reduction (antioxidant), inhibition of inflammatory mediators (anti-inflammatory), prevention of cell death (anti-apoptotic), vascular relaxation (vasodilatory), and inhibition of platelet aggregation and coagulation cascades. It also inhibits cytochrome P450 3A activity and has been shown to interact with tumor necrosis factor receptor II on regulatory T cells in cancer models. Clinically and preclinically studied for cerebrovascular diseases (e.g., stroke), cardiovascular diseases (e.g., myocardial infarction), diabetic complications (notably diabetic retinopathy), neurodegenerative disorders, metabolic diseases, organ injury protection after ischemia/reperfusion events, as well as anticancer properties against various tumor types[1][2][3][4][6].

Brand names

breviscapine

Other names

scutellarein-7-glucuronidescutellarein7-glucuronidescutellarein 7-glucuronidescutellarein-7beta-D-glucuronidescutellarein7beta-D-glucuronidescutellarein 7beta-D-glucuronidescutellarin B