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SD-1240

Development stage: Preclinical
Lead developer: University of Michigan Medical School
Modality: PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
Administration: Intravenous

Overview

**SD-1240** is a VHL-based PROTAC (proteolysis targeting chimera) degrader specifically designed to target **STAT3** (Signal Transducer and Activator of Transcription 3), a transcription factor implicated in oncogenesis. It induces potent and selective depletion of STAT3 protein, leading to suppression of tumor growth in preclinical models. SD-1240 demonstrates strong anti-proliferative effects in a subset of **acute myeloid leukemia (AML)** and **anaplastic large cell lymphoma (ALCL)** cell lines, highlighting its potential as a targeted therapy for STAT3-driven hematologic malignancies.[1][4]

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)CRBN (Cereblon)STAT1 (Signal transducer and activator of transcription protein 1)STAT4

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