SD-726

SD-726 is a highly potent and selective small-molecule degrader of Signal Transducer and Activator of Transcription 3 (STAT3), developed using Proteolysis Targeting Chimera (PROTAC) technology. Developed at the University of Michigan, SD-726 functions by recruiting the Cereblon (CRBN) E3 ubiquitin ligase to STAT3, facilitating its polyubiquitination and subsequent degradation via the 26S proteasome. STAT3 is a key oncogenic transcription factor that is frequently overactivated in various human cancers, where it promotes cell proliferation, survival, metastasis, and immune evasion. In preclinical studies, SD-726 has demonstrated the ability to achieve rapid and profound depletion of STAT3 protein levels and has shown robust anti-tumor efficacy, including complete and long-lasting tumor regression in xenograft models of anaplastic large cell lymphoma (ALCL) and other STAT3-dependent malignancies.

Other names

STAT3 degrader SD-726STAT-3 degrader SD-726STAT 3 degrader SD-726STAT3 PROTAC SD-726STAT-3 PROTAC SD-726STAT 3 PROTAC SD-726