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SD-965
- Development stage
- Unknown
- Lead developer
- University of Michigan
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
SD-965: sourced facts only. name: "Our study led to the discovery of SD-965 as a potent, selective, and efficacious STAT3 degrader." [PMID:41871272]; target: "Our study led to the discovery of SD-965 as a potent, selective, and efficacious STAT3 degrader." [PMID:41871272]; developer: "Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan 48109, United States." [PMID:41871272]; modality: "Herein, we report on the design, synthesis, and evaluation of novel STAT3 PROTAC degraders using high-affinity STAT3 ligands and cereblon ligands." [PMID:41871272]; stage: "SD-965 is capable of achieving tumor regression even with weekly administration in human leukemia and lymphoma xenograft models in mice without any signs of toxicity." [PMID:41871272]
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)
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