SD146

SD146 is an experimental small molecule belonging to the benzimidazole class and is a cyclic urea amide. It was developed as a potent inhibitor of HIV-1 protease. SD146 demonstrates high antiviral activity against wild-type HIV (IC90 = 5.1 nM) and retains or improves potency against various mutant strains of HIV that are resistant to other protease inhibitors. The compound forms extensive hydrogen bonds and van der Waals contacts with the active site of HIV protease. Despite its promising in vitro efficacy and resistance profile ("flat resistance profile"), further development was hindered by poor solubility and bioavailability[1][4][5][6].

Other names

3,3'-{[(4R,5S,6S,7R)-4,7-Dibenzyl-5,6-dihydroxy-2-oxo-1,3-diazepane-1,3-diyl]bis(methylene)}bis[N-(1H-benzimidazol-2-yl)benzamide]