SD36

SD36 is a potent and selective STAT3 (Signal Transducer and Activator of Transcription 3) degrader developed as a Proteolysis Targeting Chimera (PROTAC). It is designed to recruit the Cereblon (CRBN) E3 ubiquitin ligase to STAT3, leading to the ubiquitination and subsequent proteasomal degradation of the STAT3 protein. STAT3 is a transcription factor that is frequently overactivated in various cancers, contributing to tumor cell survival, proliferation, and resistance to therapy. By effectively depleting STAT3 levels rather than just inhibiting its activity, SD36 has demonstrated the ability to achieve complete and durable tumor regression in preclinical models of pancreatic ductal adenocarcinoma (PDAC) and hematologic malignancies. It is often studied in combination with other targeted agents, such as KRAS and EGFR inhibitors, to overcome tumor resistance and enhance therapeutic efficacy.