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Drug intelligence / Profile preview
sdBCMA2.28z CAR-T
- Development stage
- Preclinical
- Lead developer
- BC Cancer Research Institute
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
sdBCMA2.28z CAR-T is a preclinical chimeric antigen receptor (CAR) T-cell therapy designed to target B-cell maturation antigen (BCMA). It incorporates a dual human/mouse species-reactive single-domain antibody (sdAb) binder, cloned from immunized llamas, linked to CD28 costimulatory and CD3z signaling domains. This dual-reactivity allows the CAR-T cells to be evaluated in immunocompetent syngeneic mouse models (such as the Vk*MYC model of multiple myeloma) to study host-tumor-effector cell interactions and microenvironment changes, mimicking clinical settings of multiple myeloma.
- Other names
- sdBCMA2.28z CAR-T cellssdBCMA-2.28z CAR-T cellssdBCMA 2.28z CAR-T cells
02
Targets
TNFSF13 (APRIL)BAFF (Tumor necrosis factor ligand superfamily member 13B)BCMA (B-cell maturation antigen)CD28 (Cluster of Differentiation 28)CD3 (T-cell surface glycoprotein CD3)
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