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SDF Alpha
- Development stage
- Preclinical
- Lead developer
- Abeona Therapeutics
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
**SDF Alpha** is a plasma-derived alpha-1 protease inhibitor (alpha-1 proteinase inhibitor, A1-PI) developed by Abeona Therapeutics using their proprietary SDF™ (Salt Diafiltration) ethanol-free process for purification from human plasma. It functions as a serine protease inhibitor (serpin) that primarily inhibits neutrophil elastase in the lungs, protecting lung tissue from proteolytic damage in alpha-1 antitrypsin deficiency (AATD). Developed for the treatment of inherited chronic obstructive pulmonary disease (COPD) associated with congenital A1-PI deficiency, it aims to provide augmentation therapy to maintain protective serum levels of A1-PI, similar to approved products but with an improved manufacturing process to enhance purity and yield.
- Brand names
- SDF Alpha
- Other names
- SDF alpha-1 protease inhibitor
02
Targets
ELANE (Human Neutrophil Elastase)
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