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SDL-M1
- Development stage
- Phase 1
- Lead developer
- SmartDyeLivery
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
SDL-M1 is a liver-targeted nanoparticle-based therapeutic developed by SmartDyeLivery GmbH for the treatment of septic cholestasis, a severe liver dysfunction occurring during sepsis. The drug consists of a phosphoinositide 3-kinase (PI3K) inhibitor encapsulated within a functionalized polymer nanoparticle. The nanoparticle surface is modified with a polymethine dye that specifically targets Organic Anion Transporting Polypeptides (OATPs) on hepatocytes, allowing for site-specific delivery and high local concentrations in the liver. By inhibiting PI3K, SDL-M1 aims to restore the expression and activity of hepatobiliary transporters that are typically suppressed in sepsis, thereby facilitating the excretion of bile acids and bilirubin and preventing liver failure.
02
Targets
PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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