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Drug intelligence / Profile preview
SDS-20244 is a novel coumarin derivative synthesized from 7-hydroxy-4-methyl coumarin [1]. It acts as a monoamine oxidase B (MAO-B) inhibitor and exhibits neuroprotective and antioxidant properties [1]. In preclinical studies using a haloperidol-induced Parkinsonian rat model, SDS-20244 demonstrated significant neuroprotective efficacy, improving locomotor activity and motor coordination, increasing dopamine and superoxide dismutase (SOD) levels, and reducing lipid peroxidation (LPO) and acetylcholinesterase (AchE) activity [1].
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