Se@PB-ACPP

**Se@PB-ACPP** is an investigational brain-targeted nanozyme comprising selenium-loaded Prussian blue nanoparticles modified with an activatable cell-penetrating peptide. It is being evaluated preclinically as a neuroprotective treatment for Parkinson's disease. In an MPTP-induced mouse model, the material improved motor function, preserved tyrosine hydroxylase-positive dopaminergic neurons and tyrosine hydroxylase expression, reduced neuronal ultrastructural injury, and improved striatal dendritic morphology. Its proposed mechanism combines reactive-oxygen-species scavenging and anti-inflammatory activity, while the peptide modification is intended to improve brain targeting and selenium bioavailability. ([mdsabstracts.org](https://www.mdsabstracts.org/abstract/therapeutic-effect-and-mechanism-of-targeted-nano-selenium-in-mouse-model-of-parkinsons-disease-induced-by-mptp/))

Other names

ACPP-modified targeted nanoparticle-loaded selenium delivery systemselenium-loaded Prussian blue nanozyme modified with activatable cell-penetrating peptidetargeted nano-selenium