Drug intelligence / Profile preview

sea buckthorn extract

Development stage
Preclinical
Lead developer
West China Medical Center
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Sea buckthorn extract is derived from the plant Hippophae rhamnoides and consists of bioactive compounds including polyphenolic flavonoids (e.g., isorhamnetin, quercetin, kaempferol), tannins, proanthocyanidins, and triterpenes. It has numerous pharmacological effects documented in vitro, in vivo, and, to a limited extent, in clinical trials, including **antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, antihypertensive, hypolipidemic, antineoplastic, and dermatological activities**. Mechanisms of action are diverse and attributed to multi-component and multi-target effects, such as inhibition of inflammatory signaling pathways (e.g., TNF-alpha, NOD-like receptor), enhancement of antioxidant enzyme activity (SOD, GSH-Px), modulation of lipid and glucose metabolism, inhibition of platelet aggregation, and modulation of gut microbiota. Its primary indications explored in clinical studies are metabolic syndrome, cardiovascular risk factor modulation (lipids, blood pressure), hepatic disorders, and dermatological support.

Brand names
Xindakang
Other names
Hippophae rhamnoides extractsea buckthorn berry extractsea buckthorn seed oilsea buckthorn pulp oilbadriphal
02

Targets

NOTUM (Notum, palmitoleoyl-protein carboxylesterase)NOX4 (NADPH oxidase 4)GPX4 (Glutathione peroxidase 4)NLRP6 inflammasomeMisfolded SOD1TNFA (Tumor necrosis factor alpha (soluble))

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