seco-CI-MI

CI-MI (also known as seco-CI-MI) is a synthetic, highly potent duocarmycin analogue consisting of a seco-chloromethylindoline (CI) alkylating pharmacophore conjugated to a 5-methoxyindole (MI) DNA minor groove-binding motif. As an active, phenol-containing seco-duocarmycin derivative, CI-MI undergoes rapid spirocyclization to form a highly reactive cyclopropane intermediate that binds to the minor groove of DNA and selectively alkylates the N3 position of adenine in AT-rich sequences. Developed by researchers at the University of Bradford, University College London, and the University of East Anglia, CI-MI is utilized as a reference active cytotoxin in the development of tumor-targeted, cytochrome P450 (CYP)-activated duocarmycin prodrugs (such as ICT2700) designed to minimize systemic toxicity.

Other names

CI-MIseco-CI-5'-MIseco-CI-MI