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SED-087

Development stage: Preclinical
Lead developer: University of Puerto Rico
Modality: Small Molecules

Overview

SED-087 is a preclinical cyclic disulfide derivative that acts as an inhibitor of thioredoxin reductase (TrxR). Developed by researchers at the University of Puerto Rico, the compound was designed to target the redox-active sites of TrxR, which is overexpressed in various tumors and promotes cell proliferation. In preclinical screenings, SED-087 demonstrated significant cytotoxic activity against a panel of breast cancer cell lines, including MCF-7, ZR-75-1, BT-20, MDA-MB-468, SkBr-3, BT-474, and MDA-MB-231, by inhibiting cell proliferation.

Targets

TXNRD1 (Thioredoxin reductase 1)

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