Drug intelligence / Profile preview

SEL-rhBDNF

Development stage: Preclinical
Lead developer: Manzanita Pharmaceuticals
Modality: Recombinant Proteins and Enzymes, Small Molecules
Administration: Intranasal

Overview

SEL-rhBDNF is a recombinant human brain-derived neurotrophic factor (rhBDNF) therapeutic being developed by Manzanita Pharmaceuticals. It is specifically designed to target the BDNF signaling pathway for the treatment of optic pathway glioma, a form of cancer affecting the optic nerve. The drug is characterized in company literature as both a recombinant protein therapeutic and a small molecule drug-neurotrophin, suggesting a specialized formulation or mimetic approach to neurotrophin delivery. It is currently in the proof-of-concept (POC) stage of development, aiming to leverage the neuroprotective and signaling properties of BDNF to address oncological and neurodegenerative aspects of optic pathway gliomas.

Other names: recombinant human Brain-Derived Neurotrophic Factor

Targets

NTRK2 (Tropomyosin-related kinase receptor type B)

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