selective ROCK2 inhibitor

A selective ROCK2 inhibitor is a class of small molecule therapeutics designed to selectively target and inhibit Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) while sparing ROCK1. ROCK2 is a key regulator of cellular pathways involved in inflammation, fibrosis, metabolism, and gene expression. By selectively inhibiting ROCK2, these agents can downregulate pro-inflammatory Th17 cells, upregulate regulatory T cells (Tregs), and reduce pro-fibrotic signaling. Selective ROCK2 inhibitors, such as belumosudil and GV101, are being developed and utilized for various indications, including chronic graft-versus-host disease (cGvHD), multiple sclerosis, cerebral cavernous malformations, and fibrotic diseases.

Other names

ROCK2 inhibitorROCK-2 inhibitorROCK 2 inhibitorselective Rho-associated coiled-coil-containing protein kinase 2 inhibitorselective Rho-associated protein kinase 2 inhibitor