selenazole-4-carboxyamide-adenine dinucleotide

Selenazole‐4‐carboxyamide‐adenine dinucleotide is a synthetic small molecule and an organoselenium analog of the natural cofactor NAD (nicotinamide adenine dinucleotide). It is structurally related to thiazole‐based NAD analogs but features a selenium atom in place of sulfur within the heterocycle. This compound acts as a potent noncompetitive inhibitor of dehydrogenase enzymes such as inosine monophosphate dehydrogenase (IMPDH), interfering with guanine nucleotide synthesis and cellular redox processes. Its mechanism involves binding at the cofactor site of target enzymes and mimicking NAD interactions while introducing unique conformational constraints due to its selenazole moiety[7][8][9]. Selenazole derivatives have been studied for their antitumor potential due to selective uptake by tumor cells and disruption of redox homeostasis[7]. The compound remains experimental with no approved clinical indications.

Other names

Selenazole-4-Carboxyamide-Adenine DinucleotideSelenazole4-Carboxyamide-Adenine DinucleotideSelenazole 4-Carboxyamide-Adenine Dinucleotide(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(((((2R,3S,4R,5R)-5-(4-carbamoyl-1,3-selenazol-2-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)phosphinic acid{[(2R,3S,4R,5R)-5-(6-amino‑9H‑purin‑9‑yl)‑3,4‑dihydroxyoxolan‑2‑yl]methoxy}[({[(2R,3S,4R,5R)-5-(4-carbamoyl–1.3-selenazol–2–yl)–3.4-dihydroxyoxolan–2–yl]methoxy}(hydroxy)phosphoryl)oxy]phosphinic acid