selenium + tacrolimus

Selenium + tacrolimus is a combination of two agents—selenium, an essential trace mineral with antioxidant properties, and tacrolimus, an immunosuppressive calcineurin inhibitor. This combination has been studied primarily in preclinical and early clinical settings for its potential to mitigate the toxic side effects of tacrolimus (notably oxidative stress and tissue toxicity) or as a topical therapy for inflammatory conditions such as oral lichen planus. Selenium acts by enhancing antioxidant defenses (e.g., increasing heme oxygenase 1 expression), while tacrolimus suppresses immune responses by inhibiting calcineurin-dependent T-cell activation[1][3][4]. The combination is not a standard pharmaceutical product but may be used experimentally or compounded for specific indications.