selenium + zinc + ascorbic acid + thiamine + alpha-tocopherol

This intervention is an intravenous combination of antioxidant micronutrients, including selenium, zinc, ascorbic acid (vitamin C), thiamine (vitamin B1), and alpha-tocopherol (vitamin E). Developed and studied by the Centre Hospitalier Universitaire Vaudois (CHUV), it was evaluated in a Phase 3 clinical trial (NCT00515736) for its ability to reduce oxidative stress and improve organ function in critically ill patients following complicated cardiac surgery, major trauma, or subarachnoid hemorrhage. The therapy aims to replenish depleted endogenous antioxidant defenses and mitigate the intense inflammatory response associated with severe illness. The regimen typically involves a 5-day course of intravenous administration, with double-loading doses on the first two days to rapidly address micronutrient deficiencies common in the intensive care unit (ICU) setting.

Other names

ascorbic acid-Centre Hospitalier Universitaire Vaudois-critical illness-cardiac surgery-trauma-subarachnoid hemorrhageAntioxidant Supplements in Critically Ill PatientsNCT00515736 interventionNCT-00515736 interventionNCT 00515736 intervention