selenium disulfide + piroctone olamine

**Selenium disulfide + piroctone olamine** is a topical pharmaceutical combination commonly formulated in shampoos, gels, or lotions for the treatment of scalp disorders such as dandruff and seborrheic dermatitis. Selenium disulfide is an antifungal and cytostatic agent that reduces scalp flaking by inhibiting the growth of *Malassezia* species and reducing epidermal cell turnover. Piroctone olamine is an antifungal and anti-inflammatory agent that disrupts fungal cell membrane synthesis and metabolism, particularly targeting *Malassezia* and *Pityrosporum ovale* species, thus helping to control fungal populations, soothe the scalp, and reduce itching and erythema. The combination has been shown in clinical studies to achieve rapid, stable symptom relief and improved remission maintenance in moderate to severe seborrheic dermatitis of the scalp compared to monotherapy[3][4][5].