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selenium-enriched Akkermansia muciniphila
- Development stage
- Preclinical
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Selenium-enriched *Akkermansia muciniphila* is an investigational next-generation probiotic and microbial therapeutic preparation produced by inorganic selenium bio-enrichment of *A. muciniphila*. Its selenium is predominantly present in organic, macromolecule-associated forms, including protein-bound, nucleic acid-bound, and polysaccharide-bound selenium. In preclinical work, Se-AM cell lysate showed concentration-dependent cytotoxicity against CT26 murine colon carcinoma cells, while Se-AM treatment reduced tumor burden and altered inflammatory cytokines and gut-microbiota composition in CT26 colon-tumor mouse models. It has no identified commercial sponsor, marketed product, clinical trial program, or approved human indication. ([link.springer.com](https://link.springer.com/article/10.1007/s12602-025-10713-0))
- Other names
- Se-AMSe-enriched A. muciniphilaSe-enriched Akkermansia muciniphilaselenium-enriched A. muciniphilaselenium-enriched Akkermansia muciniphila
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