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Seletracetam is a pyrrolidone-derived antiepileptic drug candidate structurally related to levetiracetam. It was developed as a next-generation analog of levetiracetam with the aim of providing improved efficacy and tolerability for the treatment of epilepsy. Like levetiracetam, seletracetam acts primarily by binding to synaptic vesicle glycoprotein 2A (SV2A), modulating neurotransmitter release and reducing neuronal hyperexcitability associated with seizures. Seletracetam also exhibits inhibitory effects on voltage-gated calcium channels, which may contribute to its anticonvulsant properties. The drug was developed by UCB but its clinical development has been discontinued.
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