SELP-815K

SELP-815K is a recombinant silk-elastinlike protein polymer (SELP) developed as an injectable, in situ gelling embolic agent for the treatment of hepatocellular carcinoma via transarterial chemoembolization (TACE). Composed of repeating silk-like (GAGAGS) and elastin-like (VPGXG) peptide blocks, the polymer remains in a liquid state at room temperature, facilitating delivery through standard microcatheters. Upon reaching physiological temperature (37°C), it undergoes an irreversible phase transition to form a stable hydrogel network. This gelation allows for the selective occlusion of tumor-feeding arteries, inducing ischemia while potentially acting as a matrix for the localized, sustained release of chemotherapeutic agents. Developed primarily at the University of Utah, SELP-815K has demonstrated effective embolic capability in preclinical rabbit models, showing selective occlusion of lobar hepatic arterial branches.

Other names

silk-elastinlike protein polymer 815Krecombinant silk-elastinlike protein polymer 815K