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SELUTION SLR
- Development stage
- Unknown
- Lead developer
- Cordis
- Modality
- Small Molecules
- Administration
- Intra-arterial
01
Overview
SELUTION SLR is a sirolimus-eluting balloon (DEB) system designed for the treatment of coronary and peripheral artery diseases. Developed by MedAlliance (acquired by Cordis), the device utilizes proprietary Sustained Limus Release (SLR) technology. This technology involves biodegradable poly(lactic-co-glycolic acid) (PLGA) microreservoirs that encapsulate sirolimus, allowing for a controlled and sustained release of the drug over a period of 90 days. Sirolimus, an antiproliferative agent, acts by inhibiting the mammalian target of rapamycin (mTOR) pathway, thereby preventing neointimal hyperplasia and restenosis. The system is used for various indications, including de novo coronary lesions, in-stent restenosis (ISR), and peripheral arterial occlusive disease in femoropopliteal and below-the-knee (BTK) arteries. It has received FDA Breakthrough Device designation for BTK and coronary applications.
- Brand names
- SELUTION SLR
- Other names
- SELUTIONSelution SLR Sirolimus Eluting Balloon
02
Targets
FKBP1AmTOR (Mammalian target of rapamycin kinase)
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