semaphorin 3A lentivirus

Semaphorin 3A lentivirus is an experimental gene therapy construct consisting of a lentiviral vector engineered to express semaphorin 3A (Sema3A), a secreted protein that plays a critical role in bone metabolism, vascular regulation, and axonal guidance. In preclinical models, local administration of semaphorin 3A lentivirus (such as intratibial injection) has been shown to mitigate bone loss and osteoporosis, particularly under microgravity or tail suspension conditions, by promoting osteoblast-mediated bone formation and suppressing osteoclast-mediated bone resorption. It acts primarily by binding to the neuropilin-1 (NRP1) and plexin-A1 receptor complex, thereby modulating downstream signaling pathways like Wnt/beta-catenin and PI3K/Akt/mTOR.

Other names

Sema3A lentivirusSema-3A lentivirusSema 3A lentiviruslentivirus expressing Sema3Alentivirus-carried oe-Sema3AoeLenti-Sema3AoeLenti-Sema-3AoeLenti-Sema 3A