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senna + psyllium husk
- Development stage
- Unknown
- Lead developer
- MADAUS
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Agio-Prep is a bowel preparation regimen developed by Madaus GmbH for colon cleansing prior to colonoscopy. It is a combination product based on Agiolax-Micro, containing sennosides (derived from senna) and psyllium husk (ispaghula). Sennosides function as a stimulant laxative by acting on the colonic mucosa and myenteric plexus to increase peristalsis, while psyllium husk acts as a bulk-forming agent that absorbs water in the intestines to increase stool volume and soften consistency. The product was evaluated in a Phase 3 clinical trial in Germany comparing 3g and 6g dosing regimens against Moviprep, assessing bowel cleansing quality via the Boston Bowel Preparation Scale.
- Brand names
- Agio-PrepAgiolax-Micro
- Other names
- sennosides + ispaghula huskAgio-Prep
02
Targets
Bile acid micellesAQP3 (Aquaporin-3 channel protein)
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