Drug intelligence / Profile preview

senna alata

Development stage
Phase 1
Lead developer
University Hospital of the West Indies
Modality
Small Molecules
Administration
Topical, Oral
01

Overview

Senna alata (syn. Cassia alata) is a medicinal flowering shrub in the Fabaceae family widely used in traditional medicine for its potent antifungal and antimicrobial properties. Its leaves contain high concentrations of anthraquinones and their derivatives, including rhein, chrysophanol, and aloe-emodin, as well as sennosides and various phenolic compounds. These bioactive constituents are responsible for its efficacy against superficial fungal infections such as tinea versicolor, ringworm, and tinea imbricata. The plant's extract functions by disrupting fungal and bacterial cell membranes, inhibiting critical enzyme systems like DNA gyrase and alpha-glucosidase, and exerting anti-inflammatory and antioxidant effects. It is formally recognized in the Philippine National Drug Formulary for treating dermatophytic infections and has been the subject of several clinical trials evaluating its safety and efficacy in various topical formulations.

Brand names
Akapulko
Other names
Cassia alataCandle bushRingworm bushEmpress candle plantSeven golden candlesticks
02

Targets

CYP51A1 (Sterol 14α-demethylase)AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase

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