sennoside a

Sennoside A is a natural **dianthrone glycoside** derived mainly from medicinal plants such as Senna and Rhubarb. It is the principal active constituent of several traditional herbal remedies and is chiefly recognized as an **irritant laxative**. Sennoside A acts principally by stimulating colonic motility through direct irritation of the intestinal mucosa, which results in increased peristalsis and bowel evacuation. Beyond its established use for constipation, sennoside A exhibits diverse pharmacological actions including **anti-obesity, hypoglycemic, hepatoprotective, anti-inflammatory, anti-fibrotic, anti-tumor, antibacterial, antifungal, antiviral, and anti-neurodegenerative effects**. Its molecular formula is C42H38O20 with a molecular weight of 862.7 and low water solubility. Sennoside A is also incorporated as an active ingredient in various health supplements and weight-loss products, predominantly in Asia. Long-term or high-dose use has been associated with risks such as melanosis coli and possible carcinogenesis. Sennoside A has poor bioavailability and is metabolized by gut microbiota, which transform it to active aglycone derivatives exerting the laxative effect[1][6][4][10].

Brand names

PursenniGlysennidPursennidGlysennideSennosidePursennideSennoside A1

Other names

SennosidaSennoside ASennoside A1