Drug intelligence / Profile preview

sentinel spectrum

Development stage
Unknown
Lead developer
Novartis
Modality
Small Molecules
Administration
Oral
01

Overview

**Sentinel Spectrum** is a veterinary pharmaceutical combination product containing milbemycin oxime, lufenuron, and praziquantel. It is administered orally as a chewable tablet for dogs and provides broad-spectrum parasite protection. Milbemycin oxime acts as a macrocyclic lactone anthelmintic preventing heartworm disease (by targeting Dirofilaria immitis) and treating roundworms, hookworms, and whipworms. Lufenuron is an insect development inhibitor (specifically, a benzoylurea derivative) that interferes with flea egg development, preventing flea infestations. Praziquantel is an anticestodal agent used to treat tapeworm infections (including Echinococcus, Taenia, and Dipylidium species). The combination product is primarily indicated for the prevention of heartworm disease, control of flea populations, and treatment and control of intestinal parasite infections in dogs[2][3][9][12].

Brand names
Sentinel Spectrum
Other names
milbemycin oxime + lufenuron + praziquantel
02

Targets

GluCl (Glutamate-gated chloride channel)CHS (Chalcone synthase)CaV (Voltage-gated calcium channel protein complex)

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