Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
septin 7 siRNA
- Development stage
- Preclinical
- Lead developer
- Cleveland Clinic
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
Septin 7 siRNA is a small interfering RNA (siRNA) designed to silence the expression of the Septin 7 (SEPT7) gene. Septin 7 is a critical component of the septin cytoskeleton, which plays a significant role in regulating the activation and function of mesenchymal cells, such as myofibroblasts. In research conducted by the Cleveland Clinic, knockdown of Septin 7 using siRNA was shown to disrupt the entire septin filament network, effectively reversing the pro-fibrotic effects of transforming growth factor-β1 (TGFβ1). This genetic inhibition leads to reduced production of extracellular matrix (ECM) proteins, such as collagen and fibronectin, and attenuates the migration and cytokine secretion of activated myofibroblasts. The therapeutic potential of targeting Septin 7 is being explored for the treatment of intestinal fibrosis and strictures associated with Crohn's disease.
- Other names
- SEPT7 siRNASEPT-7 siRNASEPT 7 siRNAsiRNA for septin 7
02
Targets
Innate immune RNA sensorsSEPTIN7 (Septin-7)
Beyond the preview
Go deeper on septin 7 siRNA.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on septin 7 siRNA.