Drug intelligence / Profile preview

SER-334

Development stage: Preclinical
Lead developer: Serentrix
Modality: Small Molecules

Overview

SER-334 is a preclinical-stage small molecule transient receptor potential vanilloid 1 (TRPV1) receptor antagonist being developed by Serentrix for the treatment of acute pancreatitis. TRPV1 is a non-selective cation channel highly expressed on sensory nerve fibers that plays a critical role in pain signaling and neurogenic inflammation. By selectively blocking TRPV1 activation, SER-334 aims to alleviate pain and reduce inflammation associated with acute pancreatitis without inducing the hyperthermia side effects commonly associated with first-generation TRPV1 antagonists.

Targets

TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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