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serenoa repens
- Development stage
- Unknown
- Lead developer
- Laboratorios Q Pharma
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Serequr is a pharmaceutical-grade botanical extract of *Serenoa repens* (Saw Palmetto) developed and marketed by Laboratorios Q Pharma. It is primarily indicated for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). The extract, typically standardized to a lipidosterolic fraction, exerts its therapeutic effects through several mechanisms, including the inhibition of 5-alpha-reductase (the enzyme responsible for converting testosterone to dihydrotestosterone), anti-inflammatory activity via the inhibition of cyclooxygenase and lipoxygenase pathways, and potential anti-proliferative effects on prostatic tissue. It is an established treatment option in Europe for mild to moderate BPH symptoms.
- Brand names
- Serequr
- Other names
- Saw PalmettoSabal serrulataSerenoa repens extract
02
Targets
SRD5A (Steroid 5-alpha-reductase)ADRA1A (α1A)ALOX5 (Arachidonate 5-lipoxygenase)COXPLA2 (Phospholipase A2 group IID)
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