sericin cream

Sericin cream is an investigational topical biologic formulation containing sericin, a natural protein derived from the cocoons of the silkworm *Bombyx mori*. It is primarily developed for the treatment of uremic pruritus in patients with end-stage renal disease undergoing hemodialysis. The drug exerts its therapeutic effect by suppressing the production of pro-inflammatory cytokines, specifically tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), which are implicated in the inflammatory pathways of uremic pruritus. Clinical research conducted in Thailand has demonstrated that the cream significantly reduces pruritus intensity and improves skin hydration and irritation.

Other names

topical sericin