Drug intelligence / Profile preview

Sertraline (Torrent Pharmaceuticals)

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

Sertraline is a selective serotonin reuptake inhibitor (SSRI) developed by Torrent Pharmaceuticals as a generic bioequivalent to the reference listed drug, Zoloft (Pfizer). As a small molecule antidepressant, sertraline primarily works by binding to and inhibiting the serotonin transporter (SERT) in the presynaptic terminal. This action prevents the reuptake of serotonin, thereby increasing its concentration and prolonging its activity within the synaptic cleft, which helps alleviate symptoms of major depressive disorder and other psychiatric conditions. Torrent Pharmaceuticals has demonstrated the bioequivalence of its 100 mg tablet formulation through clinical studies comparing the rate and extent of absorption to Zoloft under both fasting and fed conditions in healthy volunteers.

Other names
Sertraline HydrochlorideSertraline
02

Targets

NET (Norepinephrine Transporter)SIGMAR1 (Sigma non-opioid intracellular receptor 1)DAT (Dopamine plasma membrane transport protein)SERT (Sodium-dependent serotonin transporter)

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