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sertraline + bupropion + venlafaxine + mirtazepine + nortriptyline + tranylcypromine + lithium
- Development stage
- Unknown
- Lead developer
- Duke University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This combination represents the antidepressant medication arm used in a Phase 1/2 clinical trial conducted by Duke University, titled "Marital Therapy and Antidepressants for Geriatric Depression." The study evaluates the efficacy of combining marital therapy with various antidepressant regimens in older adults with major depressive disorder (MDD) and marital distress. The regimen is not a fixed-dose combination but rather a selection of individually approved agents including sertraline (an SSRI), bupropion (an NDRI), venlafaxine (an SNRI), mirtazapine (a NaSSA), nortriptyline (a TCA), tranylcypromine (an MAOI), and lithium (a mood stabilizer used for augmentation). Each component targets different aspects of monoaminergic neurotransmission, such as serotonin, norepinephrine, and dopamine reuptake or metabolism.
- Other names
- antidepressant (TDDS/ODF)
02
Targets
SERT (Sodium-dependent serotonin transporter)HTR3A (5-hydroxytryptamine receptor 3A)HRH1 (Histamine H1 Receptor)HTR2A (Serotonin receptor 5-HT2A)SIGMAR1 (Sigma non-opioid intracellular receptor 1)HTR2C (5-hydroxytryptamine 2C receptor)DAT (Dopamine plasma membrane transport protein)NET (Norepinephrine Transporter)ADRA2A (α2A)
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