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SET-M33L
- Development stage
- Preclinical
- Lead developer
- SetLance
- Modality
- Peptides
- Administration
- Inhalation, Intravenous, Topical
01
Overview
SET-M33L is a synthetic, tetra-branched antimicrobial peptide (AMP) composed of L-amino acids linked by a lysine core. Developed by SetLance srl (a spin-off from the University of Siena), SET-M33L is designed to target multidrug-resistant (MDR) Gram-negative bacterial infections, including *Pseudomonas aeruginosa*, *Klebsiella pneumoniae*, and *Escherichia coli*. The peptide's unique branched structure provides enhanced stability against proteolytic degradation in biological fluids compared to linear peptides. SET-M33L operates via a two-step mechanism of action: it binds with high affinity to bacterial lipopolysaccharide (LPS) on the outer membrane and subsequently disrupts the bacterial membrane, leading to cell lysis. It is being investigated for the treatment of severe infections such as sepsis, pneumonia, and cystic fibrosis-associated lung infections.
- Other names
- SET-M33L peptideSET-M-33L peptideSET-M 33L peptide
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