setiptiline

Setiptiline is a tetracyclic antidepressant (TeCA) primarily used for the treatment of depression, especially in Japan. It acts as a noradrenergic and specific serotonergic antidepressant. Setiptiline’s mechanism of action includes antagonism at α2-adrenergic receptor, serotonin receptor (notably 5-HT2 subtypes), and histamine H1 receptor. This results in increased noradrenaline release due to presynaptic α2 blockade, modulation of serotonergic signaling via serotonin receptor antagonism or agonism (including potent full agonist activity at 5-HT1E and 5-HT1F receptors), norepinephrine reuptake inhibition, and antihistaminic effects. Its structure is closely related to mianserin and mirtazapine[1][2][3][4][6][8].

Brand names

Tecipul

Other names

setiptiline maleateteciptiline