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SeV-G(NP)

Development stage
Phase 1
Lead developer
International AIDS Vaccine Initiative
Modality
Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Intranasal
01

Overview

SeV-G(NP) is an investigational intranasal HIV vaccine candidate based on a recombinant Sendai virus vector. It is designed to express the HIV-1 Gag and Pol proteins (NP refers to nucleoprotein), aiming to stimulate both mucosal and systemic immune responses against HIV. The vaccine was developed as part of a prime-boost regimen, where it is administered intranasally followed by an intramuscular Ad35-GRIN boost. Its mechanism involves immunostimulation through delivery of viral antigens via a live attenuated viral vector, with the goal of inducing robust cellular and humoral immunity against HIV. The primary developer is the International AIDS Vaccine Initiative in collaboration with Id Pharma[1].

Other names
Sendai HIV vaccine SeV-G(NP)
02

Targets

TLR7/8 (Toll-like receptor 7 and Toll-like receptor 8)TLR3 (Toll-like receptor 3)

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