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Sex-mismatched allogeneic bone marrow transplantation
- Development stage
- Unknown
- Lead developer
- Sidney Kimmel Comprehensive Cancer Center
- Modality
- Small Molecules, Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous, Intramuscular
01
Overview
This experimental therapeutic strategy involves a sex-mismatched allogeneic bone marrow transplant (BMT) from a related female donor to a male patient with metastatic castration-resistant prostate cancer (mCRPC). The primary mechanism is the induction of a graft-versus-tumor (GVT) effect, where the donor's female immune cells recognize and attack male-specific minor histocompatibility antigens (H-Y antigens) expressed on the recipient's prostate cancer cells. The protocol incorporates post-transplant cyclophosphamide (PTCy) to selectively deplete alloreactive T cells and mitigate graft-versus-host disease (GVHD). Following engraftment, patients receive testosterone maintenance therapy, which is hypothesized to enhance the GVT effect by upregulating target antigens or promoting an immune-favorable tumor microenvironment. This study is being conducted by the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- Other names
- Sex-mismatched allogeneic BMTAllogeneic bone marrow transplantation for mCRPC
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