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SF0021 is a small molecule sodium-glucose cotransporter 2 (SGLT2) inhibitor being developed by Sarfez Pharmaceuticals. It is currently in the preclinical stage of development for the treatment of diabetic kidney disease (DKD). The drug's mechanism involves the inhibition of SGLT2 in the proximal tubule of the kidney, which reduces the reabsorption of filtered glucose and sodium. This action promotes glucosuria and natriuresis, leading to improved glycemic control and a reduction in intraglomerular pressure, which is intended to provide renoprotective effects and slow the progression of kidney damage in diabetic patients.
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