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Sf2aWC
- Development stage
- Phase 2
- Lead developer
- Walter Reed Army Institute of Research
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Oral
01
Overview
Sf2aWC is a formalin-inactivated, whole-cell oral vaccine candidate designed to prevent shigellosis caused by *Shigella flexneri* 2a. Originally developed by the Walter Reed Army Institute for Research (WRAIR) and currently being advanced by PATH, the vaccine targets the lipopolysaccharide (LPS) antigen on the bacterial surface. It is designed to induce mucosal and systemic immunity, including anti-LPS antibodies in serum and feces. Clinical evaluation includes testing the vaccine alone or in combination with the double mutant *E. coli* heat-labile toxin (dmLT) adjuvant to enhance immunogenicity and protective efficacy against gastrointestinal infection.
- Other names
- Shigella flexneri 2a whole cell vaccineInactivated Shigella flexneri 2a whole cell vaccineSf2aWC vaccineSf-2aWC vaccineSf 2aWC vaccine
02
Targets
IpaB (Invasion plasmid antigen B)IpaD (Invasion plasmid antigen D)S. flexneri 2a LPS (Shigella flexneri serotype 2a lipopolysaccharide)
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