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sGC-1061
- Development stage
- Unknown
- Lead developer
- sGC Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**sGC-1061** is a lead compound from the nomethiazole class (also known as NO-chimera prodrugs), developed as a CNS-active nitric oxide mimetic agent to improve synaptic function in Alzheimer's disease and age-related cognitive impairment. It enhances neurocognitive function in preclinical animal models, including transgenic models of Alzheimer's, by improving synaptic efficiency, lowering amyloid-beta and tau levels, and promoting cognition without targeting amyloid-beta directly. Originating from research by Prof. Gregory Thatcher at Queen's University and the University of Illinois, it was licensed to **sGC Pharma Inc.** (Wellesley, MA); a Phase 1 clinical trial confirmed high bioavailability, with a sustained-release formulation developed for once- or twice-daily dosing, positioning it for Phase 2 proof-of-concept studies post-IND in the USA.[1][3][5][7][9][11]
- Other names
- SGC 1061SGC1061SGC-1061
02
Targets
sGC (Soluble Guanylyl Cyclase)
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