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SGO1 siRNA
- Development stage
- Unknown
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
SGO1 siRNA is a small interfering RNA (siRNA) designed to target and knock down the expression of Shugoshin 1 (SGO1, also known as SGOL1), a key protein involved in protecting centromeric sister chromatid cohesion during mitosis. In laboratory research, SGO1 siRNA is widely used as a tool to investigate the role of SGO1 in chromosome segregation, spindle assembly checkpoint regulation, and cancer progression. Studies have shown that SGO1 knockdown via siRNA can inhibit the epithelial-to-mesenchymal transition (EMT), cell migration, and invasion in various cancer models, including triple-negative breast cancer and prostate cancer, making SGO1 a potential therapeutic target for preventing metastasis.
- Other names
- SGOL1 siRNASGOL-1 siRNASGOL 1 siRNASgo1 siRNASgo-1 siRNASgo 1 siRNAshugoshin 1 siRNAshugoshin1 siRNAshugoshin-1 siRNAshugoshin-like 1 siRNAshugoshin-like1 siRNAshugoshin-like-1 siRNA
02
Targets
Shugoshin-like 1 mRNA
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