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SGR-3907

Development stage: Preclinical
Lead developer: Schrödinger
Modality: Small Molecules

Overview

SGR-3907 is a preclinical-stage small molecule inhibitor developed by Schrödinger that targets the peripheral NLRP3 (NOD-like receptor protein 3) inflammasome. The NLRP3 inflammasome is a multi-protein complex that, upon activation, mediates the release of pro-inflammatory cytokines such as IL-1β and IL-18, which are implicated in the pathogenesis of various chronic inflammatory and cardiovascular conditions. SGR-3907 is specifically designed to inhibit NLRP3 activity in peripheral tissues, making it a potential therapeutic candidate for cardiovascular medicine and systemic inflammatory diseases. The program leverages Schrödinger's computational platform to optimize the molecule's potency and selectivity.

Targets

NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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