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sh-OGT
- Development stage
- Preclinical
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intraperitoneal
01
Overview
sh-OGT is a short hairpin RNA (shRNA) designed to genetically silence the expression of O-GlcNAc transferase (OGT). OGT is an enzyme that catalyzes O-GlcNAcylation, a post-translational modification that is frequently elevated in various malignancies, including prostate cancer. By targeting OGT mRNA for degradation, sh-OGT reduces the levels of O-GlcNAcylated proteins, which in turn inhibits tumor cell proliferation and enhances the sensitivity of cancer cells to chemotherapeutic agents such as docetaxel. This approach targets the miR-140/OGT signaling axis, offering a potential adjuvant strategy to overcome drug resistance in prostate cancer treatment.
- Other names
- OGT shRNAshort hairpin RNA targeting O-GlcNAc transferase
02
Targets
OGT (UDP-N-acetylglucosamine—peptide N-acetylglucosaminyltransferase)
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