sh-PMEL

sh-PMEL refers to a **short hairpin RNA (shRNA) targeting the PMEL gene**, which encodes premelanosome protein, also known as glycoprotein 100 or gp100. PMEL is a pigment cell-specific transmembrane glycoprotein essential for melanosome structure and function and is implicated as a tumor antigen in melanoma. RNA interference through shRNA targeting PMEL would be utilized to regulate, knock down, or silence PMEL expression, typically in research or investigational contexts such as cancer immunotherapy or studies of melanosome biology[1][2][7]. Such RNA-based therapeutics could potentially suppress pigment cell function, affect pigmentation, or modulate immune targeting in melanoma models.