Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
shabapisine hydrochloride
- Development stage
- Phase 1
- Lead developer
- Hefei Cosource Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Shabapisine hydrochloride is a novel small molecule topoisomerase I inhibitor developed by Hefei Heyuan Pharmaceutical. As a semi-synthetic derivative of camptothecin, it functions by binding to and stabilizing the DNA-topoisomerase I cleavage complex. This stabilization prevents the religation of DNA strands, leading to the formation of lethal double-strand breaks during DNA replication and subsequent apoptosis of rapidly dividing cancer cells. It has been primarily investigated in China for the treatment of extensive-stage small cell lung cancer (ES-SCLC), often in combination with platinum-based chemotherapy such as cisplatin. Clinical trials have focused on determining its maximum tolerated dose, safety profile, and pharmacokinetic properties in patients with advanced malignancies.
- Other names
- 盐酸沙巴哌嗪shabapisine
02
Targets
TOP1 (DNA Topoisomerase I)
Beyond the preview
Go deeper on shabapisine hydrochloride.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on shabapisine hydrochloride.