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shabapisine hydrochloride
- Development stage
- Unknown
- Lead developer
- Hefei Cosource Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Shabapisine hydrochloride is a novel small molecule topoisomerase I inhibitor developed by Hefei Heyuan Pharmaceutical. As a semi-synthetic derivative of camptothecin, it functions by binding to and stabilizing the DNA-topoisomerase I cleavage complex. This stabilization prevents the religation of DNA strands, leading to the formation of lethal double-strand breaks during DNA replication and subsequent apoptosis of rapidly dividing cancer cells. It has been primarily investigated in China for the treatment of extensive-stage small cell lung cancer (ES-SCLC), often in combination with platinum-based chemotherapy such as cisplatin. Clinical trials have focused on determining its maximum tolerated dose, safety profile, and pharmacokinetic properties in patients with advanced malignancies.
- Other names
- 盐酸沙巴哌嗪shabapisine
02
Targets
TOP1 (DNA Topoisomerase I)
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