Shandong Univ. HDAC11 compound 25

Shandong Univ. HDAC11 compound 25: sourced facts only. name: "Among the newly synthesized A9 derivatives, compound 25 stood out as a potent and specific HDAC11 inhibitor with desirable liver microsomal stability." [PMID:41787751]; target: "Among the newly synthesized A9 derivatives, compound 25 stood out as a potent and specific HDAC11 inhibitor with desirable liver microsomal stability." [PMID:41787751]; developer: "Department of Medicinal Chemistry, State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Key Laboratory of Chemical Biology (Ministry of Education), Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan 250012, P. R. China." [PMID:41787751]; stage: "Satisfyingly, compound 25 exhibited acceptable oral pharmacokinetic parameters in mouse, which supported its robust oral anti-AML potency in an MLL-AF9-induced mouse AML model, both alone and in combination with ivosidenib." [PMID:41787751]