Shandong Univ. PELI1 compound 3d

Shandong Univ. PELI1 compound 3d: sourced facts only. name: "This novel PELI1 inhibitor 3d showed potent binding affinity to PELI1 (Kd 8.2 μM) in fluorescence quenching assay, and markedly interrupted the interaction of PELI1 and SNAIL/SLUG confirmed by co-immunoprecipitation." [PMID:38150964]; target: "This novel PELI1 inhibitor 3d showed potent binding affinity to PELI1 (Kd 8.2 μM) in fluorescence quenching assay, and markedly interrupted the interaction of PELI1 and SNAIL/SLUG confirmed by co-immunoprecipitation." [PMID:38150964]; developer: "Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong, 250012, China; Weihai Marine Organism & Medical Technology Research Institute, Harbin Institute of Technology, Weihai, 264209, China." [PMID:38150964]; stage: "In the experimental lung metastasis model, 3d showed anti-TNBC metastasis efficacy without observable toxicity in vivo." [PMID:38150964]