Drug intelligence / Profile preview

Shanggan Granule

Development stage
Unknown
Lead developer
China Academy of Chinese Medical Sciences
Modality
Small Molecules
Administration
Oral
01

Overview

Shanggan Granule is a Traditional Chinese Medicine (TCM) formulation developed by the Institute of Traditional Chinese Medicine and Clinical Medicine at the China Academy of Chinese Medical Sciences. It is primarily indicated for the treatment of influenza and upper respiratory tract infections (URTI), particularly those manifesting as the "Wind-Heat" pattern in TCM diagnostics. The formulation is a complex mixture of herbal extracts, typically including *Lonicera japonica* (Honeysuckle), *Forsythia suspensa*, *Radix Isatidis*, and *Scutellaria baicalensis*. Pharmacologically, Shanggan Granule exhibits broad-spectrum antiviral activity against various influenza strains (such as H1N1 and H3N2) and possesses significant anti-inflammatory and antipyretic properties. It works by inhibiting viral replication and modulating the host's immune response, specifically by reducing the production of pro-inflammatory cytokines and preventing the progression of respiratory symptoms.

Brand names
Shanggan Keli
Other names
Shanggan GranulesShang-Gan-Ke-LiUpper Respiratory Infection Granule
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))NeuraminidaseIL-6 (Interleukin 6)NF-κB

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